2017-04-24 15:34:12Tue Dec 13 2016 11:16:30 GMT+0100 (CET)
proteinLength
154
geneLength
462
Gene
Coordinates
101,449 → 101,913
The protein
Modification
phosphorylated on Arg-55 (phosphorylation serves as tag for degradation by [[protein|ClpC]]-[[protein|ClpP]]) [Pubmed|27749819]
phosphorylation of a tyrosine residue by [[protein|McsB]] [Pubmed|14984053]
recently, it was reported that CtsR is phosphorylated by [[protein|McsB]] on Arg-62 rather than on a tyrosine residue [Pubmed|19498169]
in addition, Arg-15 was reported to be a phosphorylation site [Pubmed|22517742]
phosphorylated on Arg-55 (phosphorylation serves as tag for degradation by [SW|ClpC]-[SW|ClpP]) [Pubmed|27749819]
phosphorylation of a tyrosine residue by [[protein|McsB]] [Pubmed|14984053]
recently, it was reported that CtsR is phosphorylated by [[protein|McsB]] on Arg-62 rather than on a tyrosine residue [Pubmed|19498169]
in addition, Arg-15 was reported to be a phosphorylation site [Pubmed|22517742]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-B928 (yacG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1927 NBRP B. subtilis, Japan]
''ctsR::aphA3'' availbale in [SW|Ulf Gerth]'s lab
BKE00830 (''[[gene|ctsR]]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab)
MGNA-B928 (yacG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1927 NBRP B. subtilis, Japan]
''ctsR::aphA3'' availbale in [SW|Ulf Gerth]'s lab
BKE00830 (''[[protein|ctsR]]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab)
Biological materials
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jörg Stülke]'s lab
[SW|Categories] containing this gene/protein
[SW|proteolysis], [SW|transcription factors and their control], [SW|general stress proteins (controlled by SigB)], [SW|heat shock proteins], [SW|phosphoproteins]
Gene
Coordinates on the chromosome (coding sequence)
101,449 -> 101,913
The protein
[SW|Interactions]
[[protein|McsA]]-[[protein|McsB]]-[[protein|CtsR]]
[[protein|CtsR]]-[[protein|ClpP]]/[[protein|ClpC]] (degradation of [[protein|CtsR]]) [Pubmed|11179229,16163393,17380125]
Expression and Regulation
Operon
''[[protein|ctsR]]-[[protein|mcsA]]-[[protein|mcsB]]-[[protein|clpC]]-[[protein|radA]]-[[protein|disA]]'' [Pubmed|8793870]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|8793870], [[protein|SigB]] [http://www.ncbi.nlm.nih.gov/pubmed/8793870 PubMed1] [http://www.ncbi.nlm.nih.gov/pubmed/11544224 PubMed2]
Expression and Regulation
Regulation
induced by stress ([[protein|SigB]]) [Pubmed|11544224]
repressed at low temperatures ([[protein|CtsR]]) [Pubmed|9987115]
Expression and Regulation
Regulatory mechanism
[[protein|CtsR]]: transcription repression [Pubmed|9987115]
Expression and Regulation
Additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]